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> Discovering Dengue Drugs – Together, Phase 1 [complete], Поиск лекарств и вакцин
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May 9 2008, 17:29
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Проект "Discovering Dengue Drugs – Together - Phase 1"

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О проекте:
Старт -- Август 2007 / Статус-- активный
Поиск лекарств и вакцин от тропической лихорадки, энцефалита Западного Нила, гепатита С и желтой лихорадки. Как только посредством компьютерного анализа будет уточнен состав вакцин, начнутся лабораторные и клинические испытания этих лекарств для определения их эффективности.

Mission
The mission of Discovering Dengue Drugs – Together is to identify promising drug leads to combat the related dengue, hepatitis C, West Nile, and Yellow fever viruses. The extensive computing power of World Community Grid will be used to complete the structure-based drug discovery calculations required to identify these leads.

Significance
This project will discover promising drug leads that stop the replication of viruses within the Flaviviridae family. Members of this family, including dengue, hepatitis C, West Nile, and Yellow fever viruses, pose significant health threats throughout the developed and developing world. More than 40% of the world's population is at risk for infection by dengue virus. Annually, 1.5 million people are treated for dengue fever and dengue hemorrhagic fever. Hepatitis C virus has infected ~2% of the world's population. Yellow fever and West Nile viruses have also had significant global impact. Unfortunately, there are no drugs that effectively treat these diseases. Consequently, the supportive care necessary to treat these infections and minimize mortality severely strains already burdened health facilities throughout the world. The discovery of both broad–spectrum and specific antiviral drugs is expected to significantly improve global health.

Approach
One promising approach to combat these viruses and prevent them from causing disease is to develop drugs that inhibit the viral NS3 protease. The NS3 protease is an enzyme critical for virus replication, and its amino acid sequence and atomic structure are very similar among the different disease–causing flaviviruses. Since the atomic structure of the NS3 protease is known, we can utilize advanced structure–based computational drug discovery methods to identify small molecule protease inhibitors.

Dr. Stan Watowich and his research team at The University of Texas Medical Branch (Galveston, Texas, USA) have made significant progress in this direction, having discovered compounds that inhibit dengue and West Nile virus proteases and prevent virus replication in cell culture. However, additional drug candidates need to be discovered to improve the likelihood of converting drug leads into approved drugs for treating flavivirus infections.

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Це повідомлення відредагував Rilian: Mar 30 2010, 23:19
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Rilian
May 25 2009, 11:15
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Hello again from Galveston! Below is a status update that will be posted on our web site update board. However, I thought I would get it out via the forums as well.

Thanks again for all your help!

We are back on track with our DiscoveringDengueDrugs-Together project, and life is returning to some semblance of normalcy in Galveston and at UTMB. We thank World Community Grid members for their support and patience during the past 6 months following Hurricane Ike.

The Autodock phase (Phase 1) of our dengue project is now complete! We have screened (i.e., computationally tested) more than 3 million potential drug candidates against each of 10 different proteases from dengue, West Nile, and hepatitis C viruses. Inhibiting these target proteases prevents virus replication. We continue to analyze the 30 million Phase 1 results. We are using biochemical, cell-based, and small animal assays to characterize some of the inhibitors identified during our recently completed Phase 1 calculations.

The CHARMM phase (Phase 2) of our project is being optimized at Texas Advanced Computer Center (TACC; www.tacc.utexas.edu) in Austin, Texas and ported by IBM to the grid for testing. This phase will perform extensive molecular dynamics calculations to accurately calculate binding free energies for the best potential drug candidates predicted in Phase 1. These calculations will significantly reduce the number of false positive predictions produced in Phase 1, thereby increasing our success rate for identifying experimentally active compounds from ~10% to >80%. Launch of Phase 2 is anticipated for early summer, 2009.

As we prepare to launch Phase 2 of our project to discover drugs for dengue, West Nile, and hepatitis C infections, we will also begin Autodock calculations in support of a collaborative drug discovery effort against leishmaniasis disease. This work is done in partnership with researchers from Universidad de Antioquia, Colombia (http://www.pecet-colombia.org). Leishmania affects ~12 million people throughout the tropics, subtropics, and southern Europe, with ~2 million new cases each year. The disease is spread by the bite of sand flies infected the Leishmania parasite. Although a handful of antimicrobials exist to treat some forms of leishmaniasis, concerns about their modes of delivery, effectiveness, resistance, and cost spur our drug discovery efforts into novel anti-Leishmania drugs. For this project, scientists in Colombia identified a set of enzymes critical for survival of the Leishmania parasite. Atomic structures exist for each of these enzymes, this allowing us to computationally examine our drug candidate library for compounds that prevent the Leishmania enzymes from functioning.

As reported earlier, this project is now running better than ever before. We have moved our main computational tasks (those required to prepare workunits for World Community Grid and analyze results returned from the grid) to the supercomputers housed at TACC. This establishes a nice synergy between one of the world’s most powerful supercomputers and the world’s largest computer grid. Our storage capabilities have increased in size and robustness with redundant storage occurring at TACC and locally on our 12 TByte IBM DS3200 disk system.

As stated before, we greatly appreciate the computer time that has been unselfishly provided by the members of the World Community Grid!

- Stan


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cosmo_vk
May 26 2009, 09:45
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нипонял, этот как это фаза 1 закончена! У меня до сих пор задания висят в обработке, а по их словам 2 фаза еще только передана для тестирования в IBM.

да и по вчерашним сливам в 45 тысяч не особо это смахивает на "законченность".


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Tamagoch
Aug 4 2009, 09:22
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на сайте WCG в разделе проектов написано:
Discovering Dengue Drugs - Together
(Launched August 21, 2007; Completed August 2009)


что это значит? я уже не получу медальку? или можно попедалить? smile.gif


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Rilian
Aug 4 2009, 10:00
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ВЮ в текущей фазе проекта закончились


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Rilian
Aug 23 2009, 14:29
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Первая фаза проекта завершена 11 августа 2009

QUOTE

Just got word that we finished the last work unit at 4:55 UTC 11-Aug-2009 which means the first phase of DDD-T is complete with exception of new intermittent work from the researchers.

We would like to thank everyone for participating in this project!

-Uplinger



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Rilian
Oct 31 2009, 21:29
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Discovering Dengue Drugs – Together (Phase 1) Completion

World Community Grid is pleased to announce that as a result of the immense contribution of computing power from our members, Phase 1 of the Discovering Dengue Drugs – Together project finished on August 11, 2009.

The project launched on August 21, 2007 and ran for nearly 2 years. During that time over 159,000 members processed more than 25,500,000 results which required nearly 12,000 years of computing power from about 400,000 computers.

The project was interrupted for 17 weeks when Hurricane Ike made landfall in Galveston, Texas, USA, on September 17, 2008 and significantly damaged the research facility. Fortunately, none of the members of the research team and their families were injured and the facility was put back in working order. The project was re-started in late January, 2009.

A part of this project end, we also made some website updates. On the Research Pages and in the forums, the project is moved from Active Research to Completed Research.

Completing this project is a significant contribution to the research of Dengue Fever, Hepatitis C, West Nile, Yellow Fever and other diseases caused by the Flaviviridea family of viruses. This same research would have taken 205 years to complete on the computers that the researchers from UTMB had available to them in 2007.

Phase 1 was designed to serve as a comprehensive screening of approximately 3 million small "drug-like" molecules and identify several thousand molecules which attach to these virus enzymes in a manner that disables them. Molecules such as these may lead to drugs which can keep the disease from spreading in the body. The purpose of Phase 1 was to reduce the number of molecules being examined to only those that are the most promising candidates. These molecules will be further examined in Phase 2.

Phase 2 of the project will run each of the molecules identified in phase 1 through computationally demanding free energy calculations. The molecules that make it through this screening will be the candidates that show the most promising interactions with the virus enzymes and will be taken forward and further examined in the laboratory.


At this time, the researchers are busy performing post-processing on the results from Phase 1 and preparing for Phase 2. You may read about these plans and get the latest update from Dr. Stan Watowich in the following forum thread: http://www.worldcommunitygrid.org/forums/w...ad?thread=26616.

On behalf of the Discovering Dengue Drugs - Together research staff at the University of Texas Medical Branch in Galveston, Texas, USA, we wish to express our thanks to you for contributing your computer power to this project. With your contribution, this phase of the project was completed in a fraction of the time it would otherwise have taken.


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Rilian
Dec 12 2009, 02:39
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Видео

http://www.msnbc.msn.com/id/21134540/vp/34370816


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