Community TSC, help find drugs to fight Tuberous Sclerosis Complex Налаштування

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Официальная статистика по команде "Ukraine"

Статистика на фришниках

Статистика Украины на фришниках

Проект закрывается 15 апреля. Подробности в теме про d2ol. Последний рывок!

Join the CommunityTSC project and help find drugs to fight Tuberous Sclerosis Complex (TSC), "a genetic disorder that leads to benign tumors in multiple organs, including the brain, kidneys, heart, eyes, lungs and other organs. The project is sponsored by The Rothberg Institute for childhood diseases. The project began work on its second protein target, PI3K, on June 17, 2002. It began working on revised PTEN and PI3K protein targets and new FRAP and EIF4E targets in February, 2003. It began working on the AKT protein target on November 3, 2003. Phase I of the project was completed on April 2, 2006. Phase I statistics are available in a hall of fame.

Phase II began on April 3, 2006. Phase II is finding potential drugs for the protein target Ras homolog enriched in brain (Rheb). "The overexpression of Rheb has been shown to result in unusual overgrowth of various tissues, and is believed to be central to the growth processes underlying tumorgenesis." Phase II is also using new candidate drug libraries. The Phase I targets may be tried with the new libraries in the future. The project published a press release about Phase II on April 13, 2006.

The project tested its 1 billionth conformer in July, 2004.

The project uses the D2OL software client. On Windows the client runs in the system tray, but in all versions it also has a graphical interface and a command-line interface to allow you to watch what it's doing. It does not require a continuous Internet connection: it allows you to set the number of work units it will cache so that you can cache more work if you connect to the Internet infrequently. Note that if you pause or restart the client, you will lose all of the conformers you've generated for the current work unit. The client supports users behind firewalls. Version 2.0 of the client is available for Windows, Mac OS X, Linux and Solaris as of September 18, 2003 (see a press release about the significant updates in this version).

Це повідомлення відредагував Death: Apr 13 2009, 09:16