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> Human Proteonome Folding, Phase 2, рассчет структуры белков в человеческом теле
Rilian
Jun 11 2008, 15:33
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Human Proteome Folding Project
Phase 2


Официальные результаты проекта
Активные эксперименты
Human Microbiome Project - официальный сайт

http://homepages.nyu.edu/~rb133/wcg/thread_2010_03_10.html

Как присоединиться читайте в главном топике World Community Grid thumbsup.gif

Proteins are essential to living beings. Just about everything in the human body involves or is made out of proteins.

What are proteins?
Proteins are large molecules that are made of long chains of smaller molecules called amino acids. While there are only 20 different kinds of amino acids that make up all proteins, sometimes hundreds of them make up a single protein.

Adding to the complexity, proteins typically do not stay as long chains. As soon as the chain of amino acids is built, the chain folds and tangles up into a more compact and particular shape that lets it conduct specific and necessary functions within the human body.

Proteins fold because the different amino acids like to stick to each other following certain rules. Imagine that amino acids are pop-beads of 20 different colors. The pop-beads are sticky, but sticky in such a way that only certain combinations of colors can stick together. This makes the amino acid chains fold in a particular way that creates proteins that are useful to the human body. Human cells have mechanisms to help the proteins fold properly and, equally important, mechanisms to get rid of improperly folded proteins.

How do proteins relate to human genes?
The collection of all of the human genes is known as "the human genome." Depending on how the genes are counted, there are over 30,000 genes in the human genome. Each gene, which is a section of a long chain known as DNA, dictates how to build the chain of amino acids for one of the 30,000 proteins. In recent years, scientists were able to map the sequence for each human gene. This means that we now know the sequence of amino acids in all of the human proteins. Thus, the human genome is directly related to the "human proteome," the collection of all human proteins.

The protein mystery
While researchers have learned a great deal about the human proteome, the functions of most of the proteins remain a mystery. The genes do not reveal exactly how the proteins will fold into their final shape, which is critical because that determines what a protein can do and what other proteins it can connect to or interact with.

Proteins are like puzzle pieces. For example, muscle proteins connect to each other to form a muscle fiber. They join together in a specific manner because of their shape, as well as other factors relating to the shape.

Everything that goes on in cells and in the body is very specifically controlled by the shape of the proteins that do or do not let proteins interlock with other proteins. For example, the proteins of a virus or bacteria may have particular shapes that enable it to break through the cell membrane, allowing it to infect the cell.

The Human Proteome Folding Project
Знания структуры белков позволит ученым понять как белки выполняют свои биологические функции, а также как болезни блокируют белки от выполнения необходимых функций для поддержания здоровых клеток

The Human Proteome Folding Project will combine the power of millions of computers in a grid to help scientists understand how human proteins fold. The work to be done in this monumental task is shared across this grid, so that results can be achieved far sooner than would be possible with conventional supercomputers. With a greater understanding of protein structure, scientists can learn how diseases work and ultimately find cures for them.

When your grid agent is running, it is folding an amino acid chain in various ways and evaluating how well each folding follows the specific rules of how specific amino acids stick together or not. As computers try millions of ways to fold the chains, they attempt to fold the protein in the same way that it actually folds in the human body. The best shapes identified for each protein are returned to the scientists for further study.

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График проекта
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Це повідомлення відредагував Rilian: Feb 4 2011, 00:23
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Rilian
Jun 8 2013, 10:21
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Новых заданий осталось на пару дней! koc.gif

после этого бдут выдаваться только задания на пересчет


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Rilian
Jun 11 2013, 12:40
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Новые задания больше не выдаются

еще пару недель будут досчитываться те что уже выданы, и потом проект будет завершен! koc.gif


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Rilian
Jul 8 2013, 11:57
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Human Proteome Folding Project - Phase 2: Grid phase complete

Проект завершен!

Благодаря данным проекта выпущено 8 статей в научные журналы (см ссылку)

The grid-computing phase of the Human Proteome Folding - Phase 2 project is now complete. It was a massive project, launched in June 2006, and was the second-longest-running World Community Grid project to date. Volunteer members contributed over 123,000 CPU-years of computing power to run simulations and help determine the structure of proteins. The researchers at the Bonneau lab are very thankful to our members for this support, without which the project would have been impossible.

The researchers have made the protein structure data calculated during this project available to scientists around the world through a public database. This data has led to the publications of eight research papers in academic journals and these results have helped in better understanding the proteins involved in many diseases and have led to further research into how they might be treated. Work will continue for some time as scientists continue to analyze the protein structures.

For more details, please see the latest post from the Bonneau lab team here, as well as their more detailed recent post here.

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