Community TSC, help find drugs to fight Tuberous Sclerosis Complex Налаштування

[nikelong]

Официальный сайт

Официальная статистика по команде "Ukraine"

Статистика на фришниках

Статистика Украины на фришниках

Проект закрывается 15 апреля. Подробности в теме про d2ol. Последний рывок!

Join the CommunityTSC project and help find drugs to fight Tuberous Sclerosis Complex (TSC), "a genetic disorder that leads to benign tumors in multiple organs, including the brain, kidneys, heart, eyes, lungs and other organs. The project is sponsored by The Rothberg Institute for childhood diseases. The project began work on its second protein target, PI3K, on June 17, 2002. It began working on revised PTEN and PI3K protein targets and new FRAP and EIF4E targets in February, 2003. It began working on the AKT protein target on November 3, 2003. Phase I of the project was completed on April 2, 2006. Phase I statistics are available in a hall of fame.

Phase II began on April 3, 2006. Phase II is finding potential drugs for the protein target Ras homolog enriched in brain (Rheb). "The overexpression of Rheb has been shown to result in unusual overgrowth of various tissues, and is believed to be central to the growth processes underlying tumorgenesis." Phase II is also using new candidate drug libraries. The Phase I targets may be tried with the new libraries in the future. The project published a press release about Phase II on April 13, 2006.

The project tested its 1 billionth conformer in July, 2004.

The project uses the D2OL software client. On Windows the client runs in the system tray, but in all versions it also has a graphical interface and a command-line interface to allow you to watch what it's doing. It does not require a continuous Internet connection: it allows you to set the number of work units it will cache so that you can cache more work if you connect to the Internet infrequently. Note that if you pause or restart the client, you will lose all of the conformers you've generated for the current work unit. The client supports users behind firewalls. Version 2.0 of the client is available for Windows, Mac OS X, Linux and Solaris as of September 18, 2003 (see a press release about the significant updates in this version).

Це повідомлення відредагував Death: Apr 13 2009, 09:16

[Death]

ТСЦ как и д2ол оппа......

Dear Community TSC members,

On April 15, 2009, the Community TSC distributed computing project will officially end operations.

As this chapter in the history of The Rothberg Institute comes to a close, we wanted to take the opportunity to extend a sincere note of thanks to you, our indcredibly dedicated members who have driven every aspect of this project. We also want to take a few moments to reflect on what we have accomplished and to touch on how the project's results, thanks to your committed efforts, will be leveraged by The Rothberg Institute in the future.

As most of you know, this project set out to develop a viable platform for enabling users from around the globe to use their personal computers (whether PCs, Linux or Unix boxes, etc.) to compute the interactions of small molecule drug candidates with target molecules that likely play prominent roles in Tuberous Sclerosis Complex disease pathways. In the more than seven years that the project has been active, our members have returned results for over 150 million drug candidate-disease target tasks, utilizing over 3000 years' worth of CPU time in the process!

With the computational results available to us, we turn all of our attention toward harvesting the best possible candidates from this data
set and focusing our efforts in the laboratory in order to accomplish our original goal: finding effective real-world treatments for TSC. The Rothberg Institute remains firmly committed to this objective.

As we move forward, we will maintain our list of active and past members who have committed so much time and energy to this project, and we plan to update you periodically on the progress that we're making in the lab. Your efforts have been invaluable in moving us into position to take this next important step, and we truly appreciate the contributions that you have made.

We hope that you have enjoyed participating in this project as much as we have. For all that you have done, thank you!

The Rothberg Institute Staff

===============
что мы имеем на сегодняшний момент:

Project Rank Team Today Last Update Yesterday 2 Days Ago Average Last 7 days Last 28 Days Confs FDC RAC Nodes Cands
81 Ukraine 0 0 0 0 0 0 0 105,440 0 106 5,272



http://stats.free-dc.org/stats.php?page=te...sc&team=Ukraine