Human Proteonome Folding, Phase 2, рассчет структуры белков в человеческом теле Налаштування

[Rilian]

Human Proteome Folding Project
Phase 2

Официальные результаты проекта
Активные эксперименты
Human Microbiome Project - официальный сайт

http://homepages.nyu.edu/~rb133/wcg/thread_2010_03_10.html

Как присоединиться читайте в главном топике World Community Grid

Proteins are essential to living beings. Just about everything in the human body involves or is made out of proteins.

What are proteins?
Proteins are large molecules that are made of long chains of smaller molecules called amino acids. While there are only 20 different kinds of amino acids that make up all proteins, sometimes hundreds of them make up a single protein.

Adding to the complexity, proteins typically do not stay as long chains. As soon as the chain of amino acids is built, the chain folds and tangles up into a more compact and particular shape that lets it conduct specific and necessary functions within the human body.

Proteins fold because the different amino acids like to stick to each other following certain rules. Imagine that amino acids are pop-beads of 20 different colors. The pop-beads are sticky, but sticky in such a way that only certain combinations of colors can stick together. This makes the amino acid chains fold in a particular way that creates proteins that are useful to the human body. Human cells have mechanisms to help the proteins fold properly and, equally important, mechanisms to get rid of improperly folded proteins.

How do proteins relate to human genes?
The collection of all of the human genes is known as "the human genome." Depending on how the genes are counted, there are over 30,000 genes in the human genome. Each gene, which is a section of a long chain known as DNA, dictates how to build the chain of amino acids for one of the 30,000 proteins. In recent years, scientists were able to map the sequence for each human gene. This means that we now know the sequence of amino acids in all of the human proteins. Thus, the human genome is directly related to the "human proteome," the collection of all human proteins.

The protein mystery
While researchers have learned a great deal about the human proteome, the functions of most of the proteins remain a mystery. The genes do not reveal exactly how the proteins will fold into their final shape, which is critical because that determines what a protein can do and what other proteins it can connect to or interact with.

Proteins are like puzzle pieces. For example, muscle proteins connect to each other to form a muscle fiber. They join together in a specific manner because of their shape, as well as other factors relating to the shape.

Everything that goes on in cells and in the body is very specifically controlled by the shape of the proteins that do or do not let proteins interlock with other proteins. For example, the proteins of a virus or bacteria may have particular shapes that enable it to break through the cell membrane, allowing it to infect the cell.

The Human Proteome Folding Project
Знания структуры белков позволит ученым понять как белки выполняют свои биологические функции, а также как болезни блокируют белки от выполнения необходимых функций для поддержания здоровых клеток

The Human Proteome Folding Project will combine the power of millions of computers in a grid to help scientists understand how human proteins fold. The work to be done in this monumental task is shared across this grid, so that results can be achieved far sooner than would be possible with conventional supercomputers. With a greater understanding of protein structure, scientists can learn how diseases work and ultimately find cures for them.

When your grid agent is running, it is folding an amino acid chain in various ways and evaluating how well each folding follows the specific rules of how specific amino acids stick together or not. As computers try millions of ways to fold the chains, they attempt to fold the protein in the same way that it actually folds in the human body. The best shapes identified for each protein are returned to the scientists for further study.



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Це повідомлення відредагував Rilian: Feb 4 2011, 00:23

[Kirilkaper]

World Community Grid Lecture Series - Human Proteome Folding project

Dear ******,

You are invited to participate in a live webcast on Octover 21, 2011 to hear an overview and update on World Community Grid's Human Proteome Folding project. The event will be hosted by Dr. Richard Bonneau from New York University.

Since 2006, World Community Grid has had the privilege of supporting the innovative research underway at New York University to use computers to predict the structure of proteins, the "molecular machines" of the human body. Knowing protein structure is a critical step in advancing the understanding of how proteins affect human health, providing scientists with the information they need to develop new cures for human diseases.

This is the "Human Proteome Folding - Phase 2" project that many of you run every day on your laptops and PCs for World Community Grid, helping us make progress towards aiding researchers in understanding how proteins perform their intended functions and also how diseases prevent proteins from maintaining healthy cells.

The webcast will take place on October 21, 2011, starting promptly at 11:00AM Eastern Daylight Time (USA), which is 15:00 Coordinated Universal Time. Please join a few minutes early so that you're sure not to miss anything.

Participants can listen to Dr. Bonneau while viewing an on-screen presentation. Time permitting, you will be able to ask Dr. Bonneau questions via a text chat interface.

Access to the webcast is via this link: https://apps.lotuslive.com/meetings/join?id=0327108

You can check if your computer is ready for the webcast at this link: https://www.conferenceservers.com/browser?b...=LLENGAGE_EN-US

And whether or not you can join the webcast, make sure your laptop, PC or Mac is running World Community Grid, and let your friends know this easy way to participate in helping humanity!

Also, please note that World Community Grid has added three new download servers to help support our additional growth. Download servers are used to send work to your computer. As a result of this change, your computer may prompt you to communicate with the IP addresses of these new servers. If you have experienced this, please click on this link for further information: http://www.worldcommunitygrid.org/forums/w...ad_thread,31492


Thank you,


The World Community Grid Team

P.S. After the webcast we will post the video of the webcast on YouTube, in the World Community Grid News & Update section, and we'll send you a link to the video.