Projects 1800-1849

These projects concern the folding of the triple helix of collagen. Collagen is a major component of bone, skin, and other organs. It is in fact the most abundant protein in humans, taking a quarter of the protein mass. Collagen has a unique structure consisting of three chains wrapped around each other, hence the name triple helix. Mutations in collagen cause misfolding of the triple helix, leading to diseases such as Osteogenesis imperfecta and Ehlers-Danlos syndrome. We are studying the folding mechanism and how mutations affect it.

Points and deadlines:

• p1800 - 77 points, 23 days
• p1801 - 66 points, 20 days
• p1802 - 77 points, 23 days
• p1803 - 69 points, 21 days
• p1804 - 123 points, 35 days
• p1805 - 130 points, 37 days
• p1806 - 19 points, 10 days
• p1807 - 19 points, 10 days
• p1808 - 153 points, 44 days
• p1809 - 153 points, 44 days
• p1811 - 512 points, 141 days
• p1812 - 19 points, 10 days
• p1813 - 19 points, 10 days
• p1814 - 153 points, 44 days
• p1815 - 153 points, 44 days
• p1816 - 330 points, 92 days