FightAIDS@home, поиск лекарств от ВИЧ и СПИДа Налаштування

[mysterix]

конечно)

[Death]

Т.е. 22 мая 2014 года будет побежден СПИД?

22.05.2014 судоку дощитают ))))))

а уж спид потом на освободившихся мощностях )))

[Rilian]

Project Status, as of November 26, 2012

http://fightaidsathome.scripps.edu/status

Experiment 41: 25% Completed

Experiment 41 involves screening the Enamine library of 2.345 million compounds against the two allosteric sites on the surface of HIV protease. This experiment is similar to Exp. 36, but a different, much larger library of compounds is being screened, and some new targets are being included. The first part of this experiment involves docking compounds against the two allosteric-fragment-bound crystal structures presented in our recent article in Chemical Biology and Drug Design, vol. 75: 257-268 (March 2010). Three other, brand new crystal structures from Dave Stout's lab that involve allosteric fragments bound to these two sites on the surface of HIV protease are also being used as targets. Two of these new targets are presented in a new research manuscript from the Stout lab that is currently being peer-reviewed. When this paper is accepted, we will describe these targets in more detail and provide a link to this new paper.


This is by far the largest experiment we have submitted to FightAIDS@Home; it involves faah33,529 - faah45,253.

The results of these calculations started arriving at TSRI on 5/15/2012.

[Rilian]

WEEKLY UPDATE - based on work averaged over the last 8 weeks:

Current Batch - 36,852

Days Left - 529

End Date - May 15, 2014

также, видео от ученых проекта

Webcast and Question & Answer session replay - featuring Lead World Community Grid Scientist Viktors Berstis and Dr. Alex Perryman:

http://www.worldcommunitygrid.org/about_us...o?articleId=213



This webcast commemorated World AIDS Day 2012 and gave World Community Grid members an opportunity to hear about the cutting-edge research being done with the FightAIDS@Home project. During the webcast, Dr. Perryman outlined the exciting discoveries that he and other members of Dr. Art Olson’s computational research lab have recently made in collaboration with other research teams at Scripps and around the world. They have run simulations that identified several chemical compounds that can “dock” with allosteric sites on the HIV protease molecule and may help to inhibit its function. These compounds could form the basis of therapeutic drugs to combat HIV “superbug” strains, and at the very least they suggest compelling new avenues for further research.

And the FightAIDS@Home research will continue, thanks to the World Community Grid volunteers. The computing power supplied by the members is absolutely critical to support this research and enable these advances in HIV treatment.

As always, thank you for your support of World Community Grid research projects and please stay tuned for future webcasts!

[Rilian]

WEEKLY UPDATE - based on work averaged over the last 8 weeks:

Current Batch - 36,970

Days Left - 510

End Date - May 3, 2014

[Rilian]

WEEKLY UPDATE - based on work averaged over the last 8 weeks:

Current Batch - 37,095

Days Left - 497

End Date - April 27, 2014

[Rilian]

WEEKLY UPDATE - based on work averaged over the last 8 weeks:

Current Batch - 37,223

Days Left - 477

End Date - April 14, 2014

[Rilian]

December 30, 2012 update

WEEKLY UPDATE - based on work averaged over the last 8 weeks:

Current Batch - 37,351

Days Left - 457

End Date - April 1, 2014

Project Completion - 32.61 %

[Rilian]

WEEKLY UPDATE - based on work averaged over the last 8 weeks:

Current Batch - 37,483

Days Left - 443

End Date - March 25, 2014

Project Completion - 33.73 %

[Rilian]

WEEKLY UPDATE - based on work averaged over the last 8 weeks:

Current Batch - 37,613

Days Left - 429

End Date - March 18, 2014

Experiment 41 Completion - 34.84 %

[Rilian]

WEEKLY UPDATE - based on work averaged over the last 8 weeks:

Current Batch - 37,750

Days Left - 416

End Date - March 12, 2014

Experiment 41 Completion - 36.01 %

[Rilian]

WEEKLY UPDATE - based on work averaged over the last 8 weeks:

Current Batch - 37,879

Days Left - 402

End Date - March 5, 2014

Experiment Completion - 37.11 %

[Rilian]

WEEKLY UPDATE - based on work averaged over the last 8 weeks:

Current Batch - 37,998

Days Left - 395

End Date - March 5, 2014

Experiment Completion - 38.12 %

[Rilian]

Hi Everybody,

I just posted Volume 11 of the FightAIDS@Home Newsletter to:



http://fightaidsathome.scripps.edu/

FAAHvol11.pdf

This volume contains some of the same material that I presented in the last World AIDS Day Webinar , but I included more details and background information in the Newsletter.



Thank you all very much for your interest and your continued support,
Alex L. Perryman, Ph.D.

[Rilian]

Although I have processed and measured the results for Experiments 31 to 40, I have not yet had a chance to filter them and visually inspect the top-ranked compounds. After discovering these promising hits in Experiment 30, I've been focusing on hit-to-lead development (that is, trying to use the structures of these hits to guide the process of making larger, more potent compounds). I've also been spending a lot of time on the GO Fight Against Malaria project: preparing targets, performing and analyzing positive control studies, submitting experiments, and processing their results. I've also visually inspected and ordered new candidate compounds against two different classes of targets from the GO Fight Against Malaria project: PfSUB1 and InhA from Mycobacterium tuberculosis (which is very similar to ENR from malaria). I only need to prepare a few more classes of targets against malaria, and then I'll have more time to devote to analyzing the results of the other FightAIDS@Home experiments.

I will visually inspect and order compounds from FightAIDS@Home experiments 31 to 40, but it will take time.

Thank you very much for your interest and your support,
Alex L. Perryman, Ph.D.

Hi branjo,

Thank you very much!

I just wish the faculty search committees appreciated my unconventional, ambitious strategies half as much as you all. In the past couple years, I've applied for around 150 different Assistant Professor positions at universities throughout the U.S. (and a few in Canada and Europe, and one in Taiwan). But I've had no luck yet. If I can get a faculty position, then I'll be able to seamlessly continue and extend this research for many more years, and I'll be able to bring more personnel and other resources on board, as well. Please wish me luck on this front, too. It's still a tough job market for almost everyone, and that includes me.

Best wishes,
Alex L. Perryman, Ph.D.